Your Professional Pullulan Capsule Manufacturer in China!

 

Zhejiang Tianlong Capsule Co., Ltd. is a professional manufacturer of hollow capsules. We mainly produce 00#, 00#B, 0#el, 0#, 1#, 2#, 3#, 4# and other specifications of gelatin hollow capsules and plant capsules. At present, the company has two capsule production plants and installed 46 hollow capsule production lines,the current annual production capacity has reached 26 billion capsule.

Raw Materials

We offer a vertically integrated supply chain model to ensure reliable long-term supply, complete traceability, and superior quality of raw materials. Our raw materials pass through strict quality control assessments before going to the manufacturing stage. 

Complete Qualifications

Our plant area is strictly planned and designed according to the GMP standard for pharmaceutical excipients. We have passed ISO9001, USFDA, HALAL quality management system certification and is registered with the FDA in the United States.

OEM & ODM Service

We can provide hundreds of colors for customers to choose, but also in accordance with the customer's color card number and sample custom production.

Quality Guaranteed

Advanced automated equipment and facilities, strict indoor cleanliness procedures and perfect quality real-time monitoring, as well as high-quality raw materials to ensure that customers can provide quality products at any time.

  • Hard Shell Capsule

    Hard capsules, which are more commonly seen, are composed of a rigid shell in two pieces that fit and lock together and are then filled with the drug.

  • Vegan Acidophilus Capsule

    This formulation provides 40 million dairy free lactobacillus acidophilus organisms in a convenient vegan acidophilus capsule format, and is ideal for anyone wanting to 'top-up' their intake or for

  • Size 2 Vegetarian Capsule

    Size 2 Vegetarian Capsule, also known as veggie capsules, are made from plant-based materials such as cellulose, hypromellose, and pullulan. These materials are derived from plants such as pine

  • Pullulan Vegetarian Capsule

    Pullulan vegetarian capsules are a product in the health supplement industry, designed to meet the growing demand for vegetarian and natural products. First discovered in 1958, pullulan is a

  • Empty Pullulan Capsule

    Natural and safe — does not contain any animal ingredients, avoid the risk of zoonotic, can meet the demand of special cultural and religious beliefs.

  • Empty Safety Capsule

    Pullulan is a Biopolymer material. Its polysaccharides are water soluble by nature, through fermentation which makes it a Pullulan. These are 100% natural vegetable capsules which are edible polymer,

  • Hard Shell Capsule

    Vegetarian Pullulan capsules are designed to hold any kind of medication - herbs, vitamins, and other substances. 100% HIDE VEGETARIAN CAPSULES (100% BSE FREE).

  • Veg Capsule

    Provide consultation, selection, color selection, draft design, filling equipment debugging, technical data, test machine service.

  • Empty Vegan Pill Capsule

    The hollow capsule is composed of a cap and a body with two sections of capsule shell. Mainly used for holding solid and liquid medicine. Such as self-made powder, health care products, drugs, etc.

  • Size 0 Empty Vegetable Capsule

    The water content of the hollow capsule should be controlled between 12.5-17.5% due to its characteristics of too little water content, easy to break and too much water content, easy to soften and

  • Vegan Acidophilus Capsule

    Product Name: Pullulan Capsule. Size Available: 00#, 0#, 1#, 2#. Color: Could be customized according to samples or Panton cards.

  • Size 2 Vegetarian Capsule

    Pullulan capsule is brilliantly clear and shiny, which makes them visually attractive.. Pullulan is chemically inert and does not react or cross link with the contents.. Best choice for oxygen

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What Is Pullulan Capsule?

 

 

Pullulan is a naturally occurring, edible, bland and tasteless polymer, which is sourced from fungi grown on a starch substrate. Being a carbohydrate the pullulan capsule can act as nutrition for fillings like bifido-bacteria and improve the effect. The human body does not absorb pullulan which means that it is only the content of the capsule not the capsule itself that is obtained. Pullulan capsules can be marketed as both natural, vegetable and labeled as natural biodegradable.

 

 
Pullulan Capsule Specifications
 
01/

100% vegetarian and free of animal byproducts.

02/

Transparent filling with clearly visible contents.

03/

No ethylene oxide sterilization.

04/

Contains no preservatives.

05/

Complies with USP/ EP manufacturing regulations.

06/

No contamination from animal diseases like foot and mouth or Mad Cow.

 

What are Features of Pullulan Capsule?

Inherent Moisture Content

Maximum 5%-8%, ideal for conserving stability in water-sensitive products.

Superior Elasticity & Toughness

Exhibit top-grade resilience with substantial resistance to weathering and brittleness.

Natural & Safe

Entirely derived from pullulan polysaccharide, bereft of all harmful substances, ensures no risk of contamination.

 

Versatile Application

Universal compatibility with a range of health care products & medicines, suitable for vegetarians and aligns with diverse cultural norms.

 

Red White Capsule

 

What Are Advantages of Pullulan Capsule?

Excellent Oxygen Barrier Properties

250 times better than HPMC capsules and 9 times better than Gelatin capsules.

 

Good Stability Resulting Extended Shelf Life

Pullulan capsules are Chemically Inert. Thus no cross linking takes place with encapsulated materials. Especially suitable to protect sensitive Nutraceuticals like plant extracts, Anti-oxidants and Pharmaceutical active ingredients. Hence assures superior protection of en-capsulated substances and thus prolonged shelf life of the capsules.

 

Green and Healthy Products

No toxic chemicals involved in growing, harvesting or even extracting Pullulan. Hence it is completely Natural and Environmental friendly.

 

Glass Transparent

Enhanced transparency as compared to Gelatin & HPMC Capsules.

 

 

What Is a Pullulan and Where Does It Come From?

If you aren’t familiar with pullulan capsules and where they come from, they are made from a type of polymer. It doesn’t have any taste, ensuring the consumer doesn’t experience an aftertaste when they use such capsules. They tend to be made from natural or vegetable products.

 

There is no harm to the body from such a capsule. This is important to consumers because they don’t want to create any problems for their bodies when they take supplements or medications. Most people take supplements like this daily or they are on medications they use daily. It gives them peace of mind when the product isn’t going to be detrimental to their well-being.

 

Since pullulan capsules are durable and they aren’t vulnerable to moisture, they can be used for a wide variety of medications and supplements. They are a common type of empty shell for vitamins, oils, and more. They work well for products that are sensitive to moisture or oxygen due to their chemical makeup.

Pullulan Polysaccharides Capsule
Hard Shell Capsule

 

What Are Benefits of Pullulan Capsule?

Vegan and Vegetarian Friendly

Our Pullulan capsules are produced from cellulose and are suitable for Vegans and Vegetarians.

Mask Unpleasant Tastes

They can be used to mask the unpleasant tastes or powders by creating a layer around the ingredients.

Halal and Kosher

Depending on the ingredients and type of capsule they can be used to create halal and or kosher formulations.

Longer Shelf Life

Due to the skin they create around the ingredients capsules formulations can be created to have a longer shelf life than tablets.

Easier to Swallow

Due to their shape and texture people often find them easier than pills to swallow.

Quicker Dispersion

They allow powders to be dispensed in an uncompressed form unlike when compressed into tablets.

 

Benefits of Pullulan Capsules in Large-Scale Production

 

Pullulan is a natural polymer produced from starch by the fungus Aureobasidium pullulans. It is biodegradable, edible, and tasteless. In the pharmaceutical and food industries, Pullulan is used for its ability to form strong, oxygen-impermeable films and is often used in the manufacturing products such as food packaging and cosmetics for skin care. It is also another plant-based alternative for gelatin capsules. There are several advantages to incorporating Pullulan capsules into your production.

Superior Oxygen Barrier

Pullulan has excellent oxygen barrier properties, which is crucial for protecting sensitive compounds, such as phosphatidylcholines found in lecithin and proanthocyanidins in grape seed extract, from oxidation. This can extend the shelf life and maintain the potency of products, particularly important for nutraceuticals and pharmaceuticals that are sensitive to oxygen.

Natural Origin

Pullulan is a naturally fermented product, which can be a selling point for products marketed as natural or organic. Natural products are often seen as healthier and safer, making Pullulan ideal for the growing consumer preference for natural ingredients over synthetic or chemically modified ones.

High Gloss and Transparency

Pullulan capsules have a natural shiny appearance and are more transparent than gelatin capsules, which may be preferred for aesthetic reasons and can enhance product visibility and consumer appeal.

Allergen-Free

Like HPMC, Pullulan is allergen-free, which is increasingly important to consumers and for regulatory compliance. Using ingredients like Pullulan that are allergen-free can help build consumer trust in a brand as well as simplifying compliance with labeling requirements.

Certifications

Pullulan capsules can be certified organic, vegan, and kosher, among others, offering a broad appeal to various consumer groups and meeting diverse dietary laws and preferences.

 

Size 2 Empty Gelatin Capsule

 

Use Cases for Pullulan Capsules

Pharmaceuticals

Empty Pullulan Capsules are ideal for encapsulating medications, vitamins, and supplements.

 

Herbal Remedies

Perfect for encapsulating herbal extracts and powders, Empty Pullulan Capsules are a great alternative to gelatin capsules.

 

Nutraceuticals

Empty Pullulan Capsules provide a convenient way to encapsulate nutritional supplements.

 

Cosmetics

Empty Pullulan Capsules are suitable for encapsulating beauty serums and creams.

 

HPMC Vs Pullulan: Which Is Better for Capsules?

 

 

Source

Pullulan in capsules is made from corn starch fermentation, while HPMC is made from cotton fiber. Pullulan is completely natural, while HPMC is semi-synthetic.

Pullulan polysaccharide is derived from the fermentation of the sprouting stalk mold, hence the name sprouting stalks polysaccharide, and the main raw material is corn starch. Pullulan polysaccharide is a straight-chain polysaccharide made of maltotriose repeating unit connected by α-1,4 glycosidic bond and polymerized by α-1,6 glycosidic bond, with a molecular weight of 20,000~2 million and polymerization degree of 100~5000. It is composed of about 480 maltotrioses.

HPMC (Hypromellose), also known as hydroxypropyl methylcellulose, is one of the non-ionic cellulose mixed ethers. It is a semi-synthetic, which is made through a variety of chemical reactions and processes such as alkali immersion.

Moisture

The moisture content of pullulan capsules is about 10%-13%, while the moisture content of HPMC capsules is 5%-8%. Because of the high moisture content of pullulan polysaccharide capsules, it is not suitable for filling moisture-sensitive materials and hygroscopic powders and liquids. If filled with hygroscopic powders, it will quickly lose moisture and become brittle, losing the function of protecting the filler. But HPMC is the perfect choice.

Price

The price of pullulan is roughly twice that of HPMC, which also causes the price of pullulan capsules to be much higher than the price of HPMC capsules. This is the main reason why many manufacturers do not choose it, despite its inherently superior properties. However, with the increase and release of the production capacity of Pullulan and the innovation of technology, I think its price will slowly come down, and it will even be comparable to the cost of HMPC.

Certificates

Both Pullulan and HPMC can meet vegetarian, religious, and some special requirements. They both have certificates including Vegetarian, Non-GMO, Halal, Kosher, TSE/BSE free, Gluten/Preservative Free and in addition, pullulan can obtain the organic certificate than HPMC. Because pullulan is 100% naturally fermented, while HPMC is produced through a chemical process.

Safety

There is no safety risk to our body for both pullulan and HPMC capsules. HPMC capsules are approved for use by many national FDA authorities. The source of pullulan capsules is purely natural ingredients without any added chemical or synthetic ingredients, which is safe and healthy for our bodies.

Allergens

Pullulan capsules and HPMC capsules are free of all the most common food allergens, including peanuts, nuts, eggs, milk (milk protein and lactose), fish, shellfish, soy, wheat, barley, sesame, and gluten.

Oxygen Transmission Rate

The oxygen permeability of pullulan capsules is approximately one 300th of the oxygen permeability of HPMC capsules, under the same conditions. The oxygen transfer rate of pullulan capsules is 0.4 cm3/m2-day, while the oxygen transfer rate of HPMC capsules is 127 cm3/m2-day. Therefore, pullulan capsules are the best choice for filling oxygen-sensitive materials.

Hygroscopicity

The hygroscopicity of HPMC capsules is much lower than that of pullulan capsules because of the presence of methoxy and hydroxypropyl in the structure of HPMC, which makes it difficult to form hydrogen bonds with water. However, its water-keeping property is similar to that of Pullulan. The moisture sorption and desorption properties are critical to the drug/component that the capsule is filled with, and the amount of moisture content directly affects the activity, stability, and efficacy of the filled component.

Chemical Stability

Both pullulan and HPMC are inert, do not react with other substances, are quite stable, and are excellent raw materials for capsules.

 

Capsule Storage Guidelines
 

Safety and Storage Information

Capsules should be stored in a cool (Temperature 58 to 79°F), dry place (Humidity 35% and 55%). Keep out of direct sunlight, hot water and high temperatures.

 

Shelf Life/Expiration

Capsules generally expire five years from the date of manufacture. If stored correctly, most capsules have a shelf life of about seven years. 

 

For Powder Only

Standard vegetarian and gelatin capsules are designed for dry powders only, while vegetarian oil-grade capsules should be used for oil-based liquids.

 

 
Our Certificates

 

We always feel that all success of our company is directly related to the quality of the products we offer. They meet the highest quality requirements as stipulated in ISO9001, USFDA, HALAL and our stringent quality control system.

productcate-1000-203

 

productcate-1000-196

 

 
Automatic Production Plant

 

The plant area is strictly planned and designed according to the GMP standard for pharmaceutical excipients.

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Frequently Asked Questions

 

Q: What are the ingredients of these pullulan capsules?

A: Our pullulan capsules are a very “pure”product, with just four ingredients. The bulk of the capsule-85 to 90%-is pullulan-pullulan usp (derived from corn starch). The other 10 to 15% consists of purified water, locust bean gum and xanthan gum...all of which are natural, vegetarian ingredients.

Q: What size pullulan capsules are available?

A: All two-piece hard capsules are made in standardized sizes, with larger numbers indicating smaller-sized capsules. Our pullulan capsules are available in sizes 0 and 00, which tend to be the most popular capsule sizes overall.

Q: Are pullulan capsules suitable for all fill types?

A: Pullulan capsules are suitable for most fill types, but not all. You can safely use them with most dry ingredients, including powders, granules, beads, tablets and herbs. Be aware, however, that because of their high-water content, pullulan capsules should not be used with absorbent powders or liquid ingredients.
On the other hand, pullulan capsules should be your “go to” capsule when you need a vegetarian capsule for oxygen-sensitive fill materials. Pullulan capsules provide the excellent oxygen barrier that HPMC vegetarian capsules do not.

Q: What do pullulan capsules look like?

A: Pullulan capsules are clear and uncolored, with a shiny/lustrous appearance. Their transparency gives them a “natural”look that is ideal for natural, vegetarian products.

Q: Is pullulan capsules safe to take?

A: Pullulan is inert substance, it does no harm to human being and it is not absorbed by the body.

Q: What are vegetarian pill capsules made of?

A: Vegetarian capsule is made up of cellulose, an important structural component in plants. To be more specific, the main ingredient of vegetarian capsule is hydroxypropyl methyl cellulose (HPMC). In the current market, gelatin capsule is more broadly used than vegetarian capsule because its cost of production is lower.

Q: What are the advantages of pullulan capsules?

A: Starch Free.
Gluten Free.
Vegetable- Origin.
Not produced by Chemical Modification, like HPMC Capsules.
Preservative-Free.
Allergen-Free.
Non GMO.
Manufactured by Natural fermentation of plant extracts.

Q: What is pullulan made from?

A: Pullulan is produced from starch by the fungus Aureobasidium pullulans. Pullulan differs from most polysaccharides in that it is easily water soluble, as a result of the low degree of hydrogen bonding in its crystal form.

Q: Is pullulan digestible?

A: Pullulan and gamma-cyclodextrin are incompletely digestible, glucose-based, nonstructural carbohydrates synthesized by microorganisms.

Q: Are vegetarian capsules safe?

A: An alternative to both animal and fish gelatin is that of cellulose. This material is of natural plant origin and has no known potential health hazards, even when taken for long periods. It is non-toxic.

Q: Is pullulan FDA approved?

A: It is identified as generally recognized as safe (GRAS) by the Food and Drug Administration (FDA) in the United States (Rai et al., 2021). Coltelli and coauthors (2020) reported that pullulan has a good measure of flocculating, foaming, and adhesive properties and exhibits antioxidant and prebiotic properties.

Q: What is the difference between gelatin and pullulan capsules?

A: A big difference is that the pullulan in these capsules is made from corn starch, which is a food ingredient, while HPMC is made from plant sources that are not food ingredients. Unlike gelatin capsules, pullulan capsules are chemically inert.

Q: Are pullulan capsules organic?

A: Pullulan is water extracted from fungi grown on starch substrate, much like the mushroom growing on fertile ground.

Q: What is another name for pullulan?

A: Pullulan is a polysaccharide polymer consisting of maltotriose units, also known as α-1,4- ;α-1,6-glucan'.

Q: Is pullulan natural or synthetic?

A: Pullulan (Pullulan PI-20) with a number-average molecular weight (Mn) of about 100-200 kDa and a weight-average molecular weight (Mw) of about 362-480 kDa (Okada et al., 1990). Pullulan is a naturally occurring, fungal exopolysaccharide produced by Aureobasidium pullulans.

Q: Is pullulan a natural ingredient?

A: Pullulan is a natural, water soluble polysaccharide with excellent film-forming and binding properties and is produced from starch syrup by fermentation.

Q: Do vegetarian capsules dissolve faster than gelatin?

A: Although both capsules readily dissolve in the body at 98.6°F, vegetarian casings are more soluble or dissolve in water more easily. The plant-derived cellulose polymers are not entangled. On the other hand, gelatin polymers have cross-links on their chains that reduce their dissolving rate.

Q: What is pullulan capsule?

A: Natural pullulan capsules are a relatively new generation of high-class capsules that meets the growing market demand for more natural and vegetable products. Pullulan is a naturally occurring, edible, bland and tasteless polymer, which is sourced from fungi grown on a starch substrate.

Q: What is the use of pullulan in pharmaceuticals?

A: It has been widely used in drug targeting, implants, ocular dosage forms, topical formulations, oral dosage forms, and oral liquid formulations, etc. Pullulan can be used as a potential carrier of active ingredients and their site-specific delivery to skin layers for cosmeceutical applications.

Q: What is the difference between 0 and 00 gelatin capsules?

A: "000" holds about 1000 mg., "00" holds about 735 mg., "0" size holds about 500 mg., #1 holds about 400 mg., #3 about 200 mg. One teaspoon will fill about 7 "0" capsules and about 5 "00" capsules. The weight depends on the density of the powder you are using.

We're known as one of the most professional pullulan capsule manufacturers and suppliers in China, specialized in providing the best custom service with competitive price. Welcome to wholesale high quality pullulan capsule for sale here from our factory.

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