Medicine Capsule

Zhejiang Tianlong Capsule Co., Ltd. is a professional manufacturer of hollow capsules. We mainly produce 00#, 00#B, 0#el, 0#, 1#, 2#, 3#, 4# and other specifications of gelatin hollow capsules and plant capsules. At present, the company has two capsule production plants and installed 46 hollow capsule production lines,the current annual production capacity has reached 26 billion capsule.

The Capsule Wall Provides Protection for the Medical Ingredients Inside
Capsules act as a protective barrier for the medicinal ingredients within. Particularly when we are referring to two-piece gel encapsulation-better known as hard capsules-the capsule wall provides significant protection for the ingredients. For example, some medical ingredients are sensitive to light and may degrade when exposed to light. Since the capsule wall can be made opaque, it provides significant protection for light-sensitive ingredients.
The capsule wall can also keep out oxygen and moisture, both of which can increase the rate of degradation of the drug's active ingredients. That means a dosage form like capsulation can provide a barrier against oxygen and moisture, thus increasing the longevity of some drugs. This makes drugs not only more effective for consumers, but also helps manufacturers create more stable and marketable products.

Pharmaceutical Technology College Grads Know that Capsules Are Generally Easy to Make
A pharmaceutical manufacturing diploma can provide you with the training you need to pursue a career in pharmaceutical production and manufacturing.it may interest you to know that capsulation holds a number of benefits in terms of the manufacturing process itself. That's because manufacturing encapsulated drugs is usually much faster and simpler than manufacturing many other dosage forms.
There are a number of reasons for this. For one, capsules tend to require fewer excipients, which are bulk or filler ingredients that are designed to bulk up or bind together a drug's medicinal ingredients. With fewer excipients, capsules can be made faster, cheaper, and more lightweight than tablets or other dosage forms.because most clinical trials use capsules, once these drugs are approved for sale, they can be more easily scaled up from the clinical to the mass market stage.if the manufacturer changed the dosage form from what was used in the clinical trials, then this would lead to regulatory delays and thus slow down the manufacturing process.

Consumers Sometimes Prefer Capsules Over Other Types of Dosage Forms
As you'll learn in your pharmaceutical manufacturing courses, there are many different types of dosage forms, including capsules, tablets, ointments, creams, injectables, and pellets.capsules are one of the more common dosage forms, primarily because they are often preferred by consumers. One survey, found that 52.9% of consumers preferred capsules over other dosage forms. From a consumer's perspective, capsules offer a number of advantages.capsules tend to require fewer excipients, which means they can be made smaller and more lightweight, making them easier to swallow. Consumers especially find soft gel capsules to be easy to swallow.
Capsules can also be individually packaged, which makes them convenient for carrying around. Important information can also be printed on the capsule itself, such as the drug name, brand, and dosage size. For consumers who may be taking multiple medications, this information can help ensure they don't accidentally mix up different medicines.

Although the capsule solves the problem of premature dissolution of the medicine in the mouth, how to solve the problem that it dissolves too quickly in the stomach.
Enteric-coated capsules often use methacrylic acid copolymer and methacrylate copolymer, commonly known as acrylic resin. This resin is like a timing "alarm clock" installed on the capsule. It can control the release time and position of the active ingredients, so that the capsule will not melt until exposed to an alkaline environment, so the acid in the stomach can't dissolve the capsule, and the drug will not work until the intestine.
Successfully reaching the targeted organs is only the first step. To make the medicine in the capsule last effective, it depends on the small pills in the capsule. These small pills all have the same core that contains the drug, and they look the same, but in fact they are not exactly the same. The difference lies in the "clothes" worn outside their core. The composition of this layer of clothing is usually some organic matter with very large molecules, evenly wrapped around the core of the pellets. After the capsule is dissolved, this layer of "clothing" will slowly dissolve in the digestive tract until it disappears completely, exposing the core part. The pill will release the drug only after the core part is exposed.
If the "clothing" is made thicker, it will take more time to dissolve and the release of the drug will be delayed. If the thickness of the "clothes" is properly controlled, the medicine in the pill can be released when needed.
Thick coating layer can delay the release time of the drug, but it cannot increase the time for the drug to take effect. Even if it is possible to let the medicine take effect after 12 hours, it cannot make the effect last 12 hours. In order to solve this problem, people usually divide the small pills in sustained-release capsules into several groups and let them wear clothes of different thicknesses.
Suppose these small pills are divided into three groups. The first group is a quick-release pill without coating, the drug in this group of pill can be released immediately. The second group is a small medium-release pill, which is wrapped with a thinner coating, and the drug release rate is slower. The third group is slow-release small pills, with the thickest coating layer and the slowest release of drugs.
Pack these three groups of small pills into capsules. When the capsule is swallowed, the capsule shell first dissolves in the digestive tract, and then the quick-release pill starts to release the drug. The released drug is absorbed into the body by the gastrointestinal tract, and the drug concentration in the body gradually rises. After a while, the concentration of the drug in the body will be sufficient to produce a drug effect. At the same time, the drugs entering the body will also be metabolized and gradually excreted from the body, so the concentration of the drug starts to gradually decrease after rising. At this time, the coating layer of the medium-release pill just dissolves almost, and it also joins the ranks of drug release. When the drug concentration provided by the medium-release pill began to drop again, the slow-release pill took its place again.
After the cooperation of the three groups, the drug concentration can be maintained at a stable level for a relatively long time. In this way, sustained-release capsules remain effective for a long time.
In addition to sustained-release capsules, there are many technologies that can control the rate and time of drug release. The application of these technologies not only makes the use of drugs more convenient, but also makes the treatment effect more stable.