Zhejiang Tianlong Capsule Co., Ltd. is a professional manufacturer of hollow capsules. We mainly produce 00#, 00#B, 0#el, 0#, 1#, 2#, 3#, 4# and other specifications of gelatin hollow capsules and plant capsules. At present, the company has two capsule production plants and installed 46 hollow capsule production lines,the current annual production capacity has reached 26 billion capsule.
Why Choose Us
Raw Materials
We offer a vertically integrated supply chain model to ensure reliable long-term supply, complete traceability, and superior quality of raw materials. Our raw materials pass through strict quality control assessments before going to the manufacturing stage.
Complete Qualifications
Our plant area is strictly planned and designed according to the GMP standard for pharmaceutical excipients. We have passed ISO9001, USFDA, HALAL quality management system certification and is registered with the FDA in the United States.
OEM & ODM Service
We can provide hundreds of colors for customers to choose, but also in accordance with the customer's color card number and sample custom production.
Quality Guaranteed
Advanced automated equipment and facilities, strict indoor cleanliness procedures and perfect quality real-time monitoring, as well as high-quality raw materials to ensure that customers can provide quality products at any time.
Custom pharmaceutical grade drug in Halal natural plants cellulose print colored empty hard vegetable HPMC capsules
Custom pharmaceutical grade drug in Halal natural plants cellulose print colored empty hard vegetable HPMC capsules
Custom pharmaceutical grade drug in Halal natural plants cellulose print colored empty hard vegetable HPMC capsules
Capacity: Our annual output exceeds 26 billion capsules, which can meet the needs of customers with different purchase quantities.
Another major concern pharmaceutical companies have is patients who are vegetarians. Most of our empty gelatin capsules are made from animal products, which means they aren't a great option for those who choose to live a vegetarian lifestyle.
Halal food refers to food that meets Islamic Halal food standards. Islamic eating habits come from the canon. According to the canon, halal foods do not contain contraindications such as dead objects, blood and pork.
Function/ The stomach dissolves, disintegrates, dissolves and absorbs rapidly in the stomach. Advantages/ Low moisture content, no fragility, suitable for moisture-sensitive or hygroscopic content, such as plant source content. Suitable for all people.
Our high quality, high performance HPMC(hydroxypropyl-methyl-cellulose) capsules meet a wide range of lifestyle, cultural and dietary needs, and are also well suited to moisture-sensitive formulations.
Our high quality, high performance HPMC (hydroxypropyl-methyl-cellulose) capsules meet a wide range of lifestyle, cultural and dietary needs, and are also well suited to moisture-sensitive formulations.
What Is Vacant Hard Capsule
Vegetarian capsules are typically made of vegetable cellulose. There are several different types of vegetable cellulose that make up vegetable capsules. One of these materials is hypromellose. This type of cellulose comes from softwood trees, such as pine, spruce and fir trees.
Powder vs Capsules
One of the main advantages of using vegetarian capsules is that they can be filled with either powder or liquid supplements. This versatility allows for a wider range of supplement options and can be more convenient for consumers. Traditional gelatin capsules, on the other hand, can only be filled with powder supplements.
Easy to Digest
Vegetarian capsules are made from plant-based materials that are easily digestible. This means that they break down quickly in the stomach, allowing for faster absorption of the supplement. This is especially beneficial for those with sensitive stomachs or digestive issues. Traditional gelatin capsules, on the other hand, may take longer to break down and can cause discomfort for some individuals.
No Allergens
Another advantage of using vegetarian capsules is that they are free from common allergens such as gluten, dairy, and soy. This makes them a safe option for those with food sensitivities or allergies. Traditional gelatin capsules may contain traces of allergens, making them unsuitable for some individuals.
Longer Shelf Life
Vegetarian capsules have a longer shelf life compared to traditional gelatin capsules. This is because they are less susceptible to moisture and temperature changes, which can cause gelatin capsules to become brittle or sticky. This longer shelf life can be beneficial for supplement manufacturers and retailers, as it reduces the risk of product spoilage.
Environmentally Friendly
As vegetarian capsules are made from plant-based materials, they are biodegradable and environmentally friendly. This is in contrast to traditional gelatin capsules, which are made from animal by-products and are not biodegradable. By using vegetarian capsules, supplement manufacturers can reduce their carbon footprint and contribute to a more sustainable future.
Key Differences Between Hard and Soft Gelatin Pharma Capsules
Manufacturing Process
Soft Gelatin Capsules: Pharma Capsule Manufacturers play a big role in making soft gel capsules. In soft gel capsules, a liquid or semi-solid form of medication is filled in the outer shell. In this process of making these soft gel capsules, the four steps involved are: First, preparing the gelatin solution, which is filled in the outer shell; second, encapsulating the filling material; third, drying the capsules; and last, polishing the capsules to make their appearance good.
Hard Gelatin Capsules: Hard gelatin capsules are in two parts: the first is the cap, and the second is the body. When the pharmaceutical capsule manufacturers manufacture these hard gel capsules, the process involves dipping stainless steel pins into a gelatin solution and then cooling them to form the capsule halves. Machines then fill the capsules with the medicine formulation, seal the cap, and prepare the capsules for use.
Application Uses
Soft Gelatin Capsules: In this capsule form, there is a liquid or semiliquid form of medication, like oils, pastes, and suspensions. They are commonly used for medication, like vitamins, fish oil, minerals, and antibiotics.
Hard Gelatin Capsules: These capsules are in the form of solid capsules and powder, and granule pellets or tablets are used in these hard gel capsules. They are used for prescription and over-the-counter use, and they are widely used in antibiotics, analgesics, and herbal supplements.
Advantages
Soft Gelatin Capsules: These capsules increase bioavailability due to faster dissolution and ease of swallowing for patients who face problems swallowing big, hard tablets. They also enhance stability and sensitivity by providing a hermetic seal.
Hard Gelatin Capsules: These capsules provide advantages like precise dosage and easy identification. Companies also print their logo on them, and you can use many types of formulations in these tablets and fill them in these hard gel capsules.
Stability and Shelf Life
Soft gelatin capsules: Soft gel capsules are very stable because air, moisture, and light don't have any impact on them, which increases the shelf life of soft gel capsules.
Hard Gelatin Capsules: These capsules also have good stability when stored properly, but if they are not stored properly, they can react with oxygen, air, and moisture, which is a problem with hard gel capsules and decreases the shelf life of these tablets.
How Gelatin Capsules are Made
One of the benefits of taking in gelatin capsules is that it is made of natural food source. In previous years, these capsules are made from beef bones and purified water. thanks to technological advancements, one can also purchase vegetarian gelatin capsules. This is ideal for people with religious or dietary restrictions and cannot consume animal byproducts or have food sensitivities.
To start with, the process of creating the gelatin capsules, raw materials undergo quality testing to ensure that they are safe to use. The raw materials are placed in a petri dish and then in a specialized oven where the temperature is adjusted to stimulate growth of organisms. If the raw materials develop any growth of bacteria, then they are not safe to use. Then these are placed into a spectrometer, which burns the gelatin. The gas substance is then analyzed for any impurities. If there are no bacterial growths or impurities found, then the raw material is safe to use.
Once the gelatin passes the quality testing, it is then blended and subjected to a heating process where the gelatin will be set in. Heating temperature is set at 80C whereas the holding tanks will keep the gelatin temperature at 60C.
During the filling process, capsule shaped pens are dipped in the gelatin solution. It is then lifted off to where cool air blows over the pen to spread the solution uniformly. It will stay in the pen until the solution dries.
Once the solution dries, the caps are then removed from the pin. Using a special lever, the capsules are removed from the pins and then set on collets or holding racks where they would undergo trimming to remove the excess gelatin. The excess pieces will be sucked into a vacuum where it will then be recycled.
Once trimmed, the lot will move to a sorter to determine if there are any defects in the capsules. The batch will also pass by an automatic machine, which checks the capsules for any holes, dents or pinches. Any defective pieces are thrown to the recycle bin. Finished products will then be packed and shipped anywhere in the world.
Properties of Gelatin Capsules
Shell Composition and Characteristics
Gelatin capsules come in two standard varieties designated by their texture. The outer shell of gelatin capsules is either hard or soft. Soft gelatin capsules are more flexible and thicker than hard gelatin capsules. Regardless of rigidity, the capsules are made from water, gelatin and a plasticizers, a substance that ensures the capsule keeps it shape and texture. Soft gel capsules typically come in one solid piece while hard gel capsules are made of two pieces placed together.
Content Characteristics
Soft gel capsules contain liquid or oil-based medications, or medicines mixed or dissolved in oil, notes the book "Pharmaceutical Capsules." Hard gelatin capsules generally contain dry or powdered substances. The manufacturing process for each type of gel capsule makes each type more suited to its contents.
Content Composition
Gel capsule contents can also be classified by certain characteristics. All medications are either hydrophilic or hydrophobic. Hydrophilic medications readily mix with water while hydrophobic medications don't. Medications in oil form or mixed with oil, like those typically found in soft gel caps, are hydrophobic. Powdered or solid medications, which are typically found in hard gel caps, tend to be hydrophilic. Additionally, the substance inside a soft gel capsule can be a suspension of large particles floating and not mixing in the oil, or a solution in which the ingredients are completely mixed.
Digestibility
Gelatin is a protein made from animal skin or bones. These proteins lend easy digestibility to the capsules. In certain cases, medication enclosed in gelatin capsules enters the system quicker than with other medication types. Vegan gelatin capsules are made from cellulose, a plant fiber, which is harder for the body to digest than animal fiber.
Airtight Seal
Gelatin capsules are airtight. This is particularly useful for liquid medications. If the same liquid medications were sold in an unencapsulated form, the contents might go bad before the consumer could use the entire contents of the bottle. The airtight seal created during the manufacture of gel caps prevents potentially harmful microorganisms from forming in the medication. Gelatin capsules offer single-serve doses of medications with a longer shelf life compared to their liquid counterparts.
Brittleness in Gelatin Capsules: How to Overcome the Challenge
Gelatin capsules constitute a major share of the capsule market today. The prediction that the global market of capsules is expected to grow from $1.5 billion in 2016 to $2.21 billion in 2021 shows that gelatin capsules are still performing well, irrespective of the other capsule options available in the market.i The long-term usage and safety record of gelatin capsules indicate that they are a reliable dosage form. Although gelatin capsules have many desirable properties for a dosage form, certain other properties of gelatin must be considered more closely during product development. One such property is the potential of gelatin capsules to lose moisture and become brittle when they are stored at low relative humidity (RH), contain hygroscopic formulations, or are exposed to desiccants. Gelatin capsules usually tend to become brittle at an RH below 40%.
Before we move on to consider the different approaches that can be adopted to reduce the brittleness of gelatin capsules, the property of brittleness should first be understood. A material is said to be brittle when it breaks without undergoing permanent distortion. This property is exactly opposite to elasticity, which is defined as a material's ability to be stretched or deformed and then be able to return to its original size. Elasticity is observed when a material (a polymer, in the case of gelatin capsules) is subjected to force; this energy is accommodated through various processes, such as deformation, molecular movements (vibration, rotation, and small translations), and heat. However, such modes of movement are not observed in brittle materials. Instead, the force applied is confined within a small localized area, causing the direct rupture of bonds.
Hard gelatin films often require plasticizers during preparation to reduce the stiffness of the gelatin. Along with the polymer, plasticizers reduce the cohesive intermolecular forces and impart a degree of flexibility. Water (13–16% w/w)ii is the most commonly used plasticizer in hard gelatin capsules.at low RH, the capsules lose moisture and become brittle.
Our Certificates
We always feel that all success of our company is directly related to the quality of the products we offer. They meet the highest quality requirements as stipulated in ISO9001, USFDA, HALAL and our stringent quality control system.
Automatic Production Plant
The plant area is strictly planned and designed according to the GMP standard for pharmaceutical excipients.
FAQ
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