1. Hydroxypropyl methyl cellulose is widely used as the adhesive and aftercoating agent of tablets as a pharmaceutical excipient. It is safe and reliable when taken with many drugs.
2. Hydroxypropyl methyl cellulose has stable chemical properties, does not react with air and water, and is inert in metabolism. It is not absorbed in the body and is directly discharged from the body. It is not easy for microorganisms to grow, so under normal conditions, it will not decompose and deteriorate after being placed for a long time.
3. Compared with the traditional gelatin hollow capsule, the plant capsule has the advantages of wide adaptability, no risk of cross-linking reaction and high stability. The drug release rate is relatively stable, with small individual differences. It is not absorbed after disintegration in the human body, and can be excreted with excreta.
In terms of storage conditions, through a large number of tests, it is almost not fragile under low humidity conditions, and the capsule shell properties are still stable under high humidity conditions, which will not affect the indicators of plant capsules under extreme storage conditions.
Gelatin capsules are easy to adhere under high humidity conditions, and harden or brittle under low humidity conditions. Gelatin capsules are highly dependent on the temperature, humidity and packaging materials of the storage environment.
4. After the plant hydroxypropyl methyl cellulose is made into the capsule, it still has the natural concept. The main component of the hollow capsule is protein, so it is easy to breed breeding bacteria and microorganisms. Preservatives need to be added in the production process, so there may be a small amount of Nipagin type preservatives left on the capsule, and the finished product needs to be sterilized by ethylene oxide before packaging to ensure the microbial control indicators of the capsule. For gelatin hollow capsules, chloroethanol is a strictly controlled indicator. The plant capsule does not need to add any preservatives and ethylene oxide sterilization in the production process, which fundamentally solves the problem of chloroethanol residue.
5. The demand for plant capsules will grow rapidly in the future. Although it is impossible for plant capsules to replace the dominant position of traditional gelatin hollow capsules, plant capsules have obvious competitive advantages in Chinese traditional medicine preparations, biological preparations and functional foods, with advantages such as wide applicability, no risk of cross-linking reaction, high stability, and no moisture absorption.
