Zhejiang Tianlong Capsule Co., Ltd. was founded in 1987 and is a professional manufacturer of hollow capsules. At present, the company has two capsule production plants and 46 hollow capsule production lines installed. The plant area is strictly planned and designed according to the GMP standard for pharmaceutical excipients. The layout is scientific and reasonable. It has passed ISO9001 quality management system certification and is registered with the FDA in the United States.
Why Choose Us
Our Product
Gelatin Empty Hard Capsules:Gelatin empty hard capsules are the most widely used all around the world at present.
HPMC Empty Hard Capsules: Low water content, suitable for water sensitive components.No risk of cross-linking reaction.The structure of elastic polymer ensures the stability of the capsule and the high filling rate.
Pullulan Empty Hard Capsules:Pullulan capsules used pullulan polysaccharides (fermented from corn) as main raw material, produced by special dipping and drying process.
Our Certificate
We always feel that all success of our company is directly related to the quality of the products we offer. They meet the highest quality requirements as stipulated in ISO9001, USFDA, HALAL and our stringent quality control system.
Main Market
Products are also exported to Europe, the Americas, Africa, Central Asia, the Middle East and many other countries and regions. Has won wide recognition in the global pharmaceutical and health industry.
Our Service
Corrective actions by responding quickly to any quality request or issue and collaborating in trouble-shooting on your capsule-filling line.
Preventive actions by being on hand to advise and anticipating any changing situations in production requirements. Additionally, on your demand, we can organize training activities for operators, or whom you decide, in capsule-filling production areas.
The raw material of our gelatin capsules is sourced from Dongbao and Rousselot, the largest suppliers of high quality bovine bone gel. The process of manufacturing gelatin capsules and operation is in accordance with GMP standards.
Empty capsules by medical gelatin caps with auxiliary materials refined but become, body two capsule shells. It is mainly used for holding solid drugs.Such as homemade powder, health care products, pharmaceutical, etc.
Empty capsules by medical gelatin caps with auxiliary materials refined but become, body two capsule shells. It is mainly used for holding solid drugs. Such as homemade powder, health care products, pharmaceutical, etc.
Materials/ gelatin, our company only uses bovine bone gelatin.
Function/ rapid dissolution, can quickly disintegrate in the stomach, is conducive to the rapid release of the contents.
Empty (Vacant) capsule is one of the most common choices for medicine filling, and it has acquired an important position in the industry of medicine manufacture.
Every day more and more people are learning about the benefits of gelatin capsules and naturally it begs the question, just how are gelatin capsules made? The quick answer is that they're made with natural ingredients, using time-tested and safe methods.
Tianlong is handled by well-experience team of technical and professional staff to committed to provide the Domestic and International Pharmaceutical industries with capsules suited for all type of filling machines.
Empty capsules by medical gelatin caps with auxiliary materials refined but become, body two capsule shells. It is mainly used for holding solid drugs. Such as homemade powder, health care products, pharmaceutical, etc.
Culture is the lifeblood of sustainable development of enterprises. Tianlong always emphasis on corporate culture, instill the corporate values and operation philosophy into staffs in order to create a team with high cohesion and great loyalty.
What Is Empty Pill Capsule
Pharmaceutical empty capsules are used for packaging powders, pellets, or tabletted mixtures containing active ingredients that elicit desired therapeutic effects upon administration. This practice extends beyond drug products as empty capsules are the most common option to store herbs and non-pharmaceutical powder preparations, amongst other substances.Using empty capsules to make homemade supplements is a simple process. Many people use empty capsules to make their own vitamins and herbal concoctions, which can be more cost-effective than purchasing such products from the market.
Energy and time saver
Once manufacturers produce them, they fill hard, unfilled capsules with powder or liquid. The clear-cut nature of this template means that pharmaceutical companies may save time and energy filling it out.
Compatibility
Hard empty capsules provide versatility, enabling their use with many different medications. Encapsulate health-boosting substances.
The capacity to successfully encapsulate various compounds is essential in the pharmaceutical and dietary supplement sectors. Hard, empty capsules made of gelatin or HPMC are adaptable since they can hold liquids and solids.
Preserving Active Ingredients
Gelatin capsules are popular because they can maintain the efficacy and stability of their contents for a long time. By protecting the encapsulated material, it extends its shelf life and ensures its effectiveness.
Gelatin can protect fragile things from damage. It does this by sealing out air, moisture, and light. Gelatin doesn't react with other substances. The product's economic viability pivots on how long it continues to perform as intended.
Reduced Risk of Allergies
Some patients may struggle to swallow gelatin capsules with their medicine because of food allergies or religious beliefs against animal products. HPMC pills are great for people who have substance allergies because they are hypoallergenic and vegan. It will lead to fewer customers rejecting your products.
Choosing the Perfect Empty Capsules Sizes
Weight
We give them headline size designations (sizes 000 through 5) for easy selection, but there's more to it than that. For instance, while we've been talking about milligrams (mg) so far, that's actually the weight - and for the very same capsule size, the density of the filler matters, as will the precise mg value you'll record on the scales.
Tip: Whether it's broken down on the size chart or not, vegetarian capsules tend to weigh just a tiny bit more than standard gel capsules.
Volume
Distinct from the weight is the volume - and that is measured by the millilitre (ml). Unlike average weight, the volume is exact per capsule size because it's a measure of the empty space within your empty gelatin capsules. However, good size charts may also convert the volume in ml into an easier-to-understand metric of capsules per teaspoon - which is invaluable for lovers of buying their own gelatine capsules as they may be more accustomed to simply measuring out doses with the trusty teaspoon.
Dimensions
Empty gelatin capsules, of course, are comprised of two parts so that you can fill them and click them together before swallowing. The dimension of your capsules measures the entire length of the clicked-together capsule, but good charts of standard gelatin capsule sizes will also include the body diameter as well - which is crucial, as it's usually the diameter rather than the length alone that determines just how hard that "gulp" will have to be.
Density
As we've already alluded to, the weight of your capsule is not most importantly about its empty form, but what it will show on the scales just before it's gulped down. As there are all sorts of different filler densities, the density per individual capsule of the exact same size can vary quite significantly. For instance, a topped-up capsule with a light powder inside might be 0.6 grams per millimetre (g/ml), but a medium or heavy density could tip the scales at 0.8g/ml, 1.0g/ml, all the way up to 1.2g/ml or even slightly more.
The Ingredients Used in Capsule
Plasticizer (E.g. Sorbitol, glycerin, etc.)
Plasticizers are added to capsule shells to reduce the rigidity of the polymer and make it more pliable. The ratio of plasticizer and gelatin is lower in hard gelatin capsules, approximately 0.4 : 1.
Water
Varies depending on storage conditions.
Opacifiers (E.g. Tio2)
They provide protection against light and photodegradation. They also play a role in concealing the contents used in the filling of capsule shells.
Colorants (E.g. Dye, Lakes, Mineral Colors, etc.)
Coloring agents can impart various colors to hard gelatin capsules. Colorants play an important role in improving patient compliance and can be further selected to complement the disease being treated.
Capsules Filling Process
Different capsule filling machines are available for the effective filling of the capsules. Below is a quick overview of how capsules can be filled:
Simple steps for hard gelatin capsule filling
- First, take the removable plate and locate the empty gelatin capsules. You need to be sure about the downward-facing position.
- Separate the cap and bodies properly.
- Use a plastic spatula to fill the formulation into the capsule body. The excess powder has to be removed from the capsule.
- In the last step, close the filled capsule shells. Now, eject the capsule.
Manual powder formulation filling
Manual powder filling to the hard gelatin capsules is vital for different purposes. Capsule manufacturing and research are some of them! If your want to know how gelatin capsules are made manually, the following steps can tell you how to do it:
- Place the powder to be filled on a porcelain plate or clean paper.
- Move ahead by pressing the capsule's open end in the downward direction.
- You should press until the capsule is filled.
- Lastly, use the cap on the capsule to close it.
How Do Capsules Dissolve In Your Body
Here's a simple breakdown of what happens when you take a capsule:
Swallow the capsule
It all starts when you swallow the capsule with some water. It goes down your esophagus and lands in your stomach.
Contact with stomach fluids
Once in your stomach, the capsule encounters stomach fluids that contain gastric acids and digestive enzymes. These fluids cause the capsule's shell to start melting.
Breakdown of the capsule shell
For immediate-release capsules, the gelatin shell disintegrates quickly in the acidic environment of the stomach. However, enteric-coated capsules are designed to resist the stomach's acidity and dissolve later in the intestines.
Release of contents
When the shell breaks down, either in the stomach or intestines, the capsule's contents are released. Whether it's powders, liquids, or pellets, they mix with your digestive fluids.
Absorption
The released contents, like medications or supplements, enter your bloodstream through the walls of your stomach or small intestine, where they start working.
Final breakdown and elimination
Any material that isn't absorbed continues through your digestive system. It gets broken down further and eventually leaves your body as waste.
There are several things you can do with empty gelatin capsules. And considering the versatility of these products, it's no wonder that they've become so popular. Here are some of their primary functionalities:
Use in the pharmaceutical space
As you would expect, the most prominent thing that empty gel capsules are used for is to make medicine. With these capsules, you can easily get accurate dosages without much stress.
Taking herbal supplements
There are several botanical extracts and herbal supplements that are also taken in the form of gelatin capsules, with their ability to help you take them in a measured form.
Using custom blends effectively
If you're creating a custom blend of supplements that can't be found in most pharmacies, then you'll probably need these capsules to effectively take them.
Formulations for probiotics
There are a few custom probiotic formulations that are built in the form of gelatin capsules. With the capsules, you can protect your bacteria content from any environmental elements.
Capturing aromatherapy formulations
Aromatic substances, essential pills, and more can be made in the form of gelatin capsules. With the capsules, you can easily control your dosage of these materials significantly.
Pharmaceutical research applications
Before a drug is launched into the market, its developers will need to first research and experiment with it. Everything from the formulations to the sizes of capsules needs to be tested, and empty gelatin capsules make it possible to do that.
Even animals use them
Just like humans, animals need to take medications from time to time. In the veterinary space, gelatin capsules can be used to provide the right types of medications to animals.
Applications in the beauty industry
Beauty powders, serums, and more can be formulated into capsules as well, making them comparatively easier to consume.
Consumption of cannabis-based products
Cbd is already one of the most popular materials in the world. And capsules are among the many formulations available.
Reasons Why Empty Hard Gelatin Pill Capsules Become Brittle and Crack
Gelatin capsules are a common form of pharmaceutical packaging used to encapsulate various forms of medication. They are designed to be robust and easy to handle, yet they can sometimes become brittle and crack, leading to concerns about their integrity and the safety of the medication they contain. Gelatin is a protein derived from collagen, which is found in animal tissues. It is processed to create a substance that can be easily molded into the shape of a capsule. The capsule consists of two halves that fit together, providing a sealed environment for the medication inside.
Humidity and Moisture
One of the primary reasons for empty gelatin pill capsules to become brittle is exposure to humidity and moisture. Gelatin is hygroscopic, meaning it has the ability to absorb water from the environment. When capsules are exposed to high humidity levels, they can absorb excess moisture, leading to a change in their physical properties and making them more susceptible to cracking.
Temperature Fluctuations
Temperature changes can also have a significant impact on the integrity of empty hard gelatin capsules. Sudden shifts from cold to warm temperatures or vice versa can cause the gelatin to expand and contract, leading to stress points and potential cracking. Store the capsules in a stable environment at a consistent temperature to maintain their structural integrity.
Age of the Capsules
The age of the capsules can play a role in their tendency to become brittle. Over time, the gelatin can degrade, leading to a loss of flexibility and an increased likelihood of cracking. This is particularly true for capsules that have been stored for extended periods without being used.
Manufacturing Defects
Manufacturing defects can also contribute to the brittleness and cracking of gelatin capsules. Imperfections in the molding process, such as uneven thickness or the presence of air bubbles, can weaken the structure of the capsule and make it more prone to cracking.
Mechanical Stress
Handling gelatin capsules with excessive force or dropping them can cause mechanical stress, leading to cracks or breakages. It is essential to handle capsules gently and with care to prevent damage.
Chemical Interactions
Certain chemicals, either from the environment or from the medication inside the capsule, can interact with the gelatin and cause it to become brittle. For example, some medications may contain substances that can degrade the gelatin over time, affecting its structural integrity.
Storage Conditions
Inadequate storage conditions can contribute to the brittleness and cracking of gelatin capsules. Exposure to direct sunlight, high temperatures, or extreme cold can all have negative effects on the gelatin. Store capsules in a cool, dry place away from direct sunlight and temperature fluctuations.
Quality of Gelatin
The quality of the gelatin used in the manufacturing process can also impact the capsules' tendency to become brittle. Low-quality gelatin may not have the same structural properties as higher-quality gelatin, making it more susceptible to cracking.
Design of the Capsule
The design of the capsule itself can play a role in its susceptibility to cracking. Capsules with thinner walls or those that are not uniformly shaped may be more prone to cracking under stress.
Presence of Fillings
Overfilling or using a filling that is too hard can put additional pressure on the gelatin walls, increasing the risk of cracking.
The empty pill capsule is mainly used for containing solid drugs, such as homemade powder, health care products, medicines, etc., and solves the problem of bad tastes. Capsules have good bioavailability and dissolve quickly, reliably and safely, so they are very popular.
Because the average water content of empty capsules is 12% to 15%. If the capsule is improperly stored, it will absorb water or dehydrate, resulting in a change in the diameter and shape of the capsule. It is therefore important to understand the storage conditions of the empty capsules for the user.
1. The water content of the gel capsule is too little, it is easy to be broken, and too much is easy to soften and deform, therefore the water content should be controlled between 12.5 and 17.5%.
2. Containers with capsules should be placed on the shelves in a cool, ventilated place, avoiding windows and pipes where can get sunlight and heat.
3. It cannot be stressed.
4. Before use, the packaging container of the capsule should be kept sealed; if it is already opened, please take corresponding sterilization measures, otherwise it will cause bacterial contamination.
5. The stock temperature should be maintained at 15 - 25 ° C; the relative humidity should be maintained at 35 - 65%.
6. The product cannot be stored under high temperature and high humidity conditions, otherwise it will be blocked and deformed due to heat becoming soft; it cannot be placed in an environment where the temperature is too low or too dry, otherwise the capsule is prone to brittle.
FAQ
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